Whereas low-rely MBL not often progresses to CLL, higher-rely MBL progresses to CLL requiring therapy in a rate of 1% to 2% a year. Significant-depend MBL is distinguished from Rai 0 CLL based upon whether or not the B-cell depend is previously mentioned or down below five × 109/L. Though men and women with equally substantial-depend MBL and CLL R